Combat is relatively simple in Isleward.
You can target a monster by left-clicking on it. Walk toward the monster to get within range of your weapon and press
space to engage auto-attack for your main weapon. Attacking a monster will cause it to retaliate. Some monsters may also automatically attack you if the player gets too close (Eagles, Bandits hideout mobs, Estuary mobs and Temple mobs).
The monster or your character dies when its HP is depleted to zero. You can view your current HP at the top left corner (red gauge). If you are killed in combat, you will respawn (unless you are Hardcore, in which case your death is permanent), and the monster's HP will be healed to full. Once a monster is killed, you will gain experience and it may drop loot for you to pick up by walking over it.
Runes also provide additional abilities to assist you in combat, such as dealing damage or healing yourself. You can learn up to four runes at a time, and activate their abilities by pressing
4. Runes require mana to use, which can also be seen at the top left corner (blue gauge). Some runes also require time to cast and have cooldown before the same rune can be used again.