Combat is relatively simple in Isleward.
You can target a monster by left-clicking on it. Walk toward the monster to get within range of your Weapon and press the keyboard button
1 to engage auto-attack for your main weapon. Attacking a monster will cause it to retaliate.
The monster or you dies when its HP is depleted to zero. You can view your current HP at the top left corner. If you are killed in combat, you will respawn (unless you are Hardcore, in which case your death is permanent), and the monster's HP will be healed to full. Once a monster is killed, you will gain experience and it may drop loot for you to pick up by walking over it.
Runes also provide additional abilities to assist you in combat, such as dealing damage or healing yourself. You can learn up to three runes at a time, and activate their abilities by pressing
4. Runes requires mana to use, which can also be seen at the top left corner.
You can also form a party with other players to defeat more difficult monsters, and to shared loot and experience.